Listed in the 1860 census, Red Rock District, 3 doctors were in Gladewater and all 3 were from South Carolina. There was Dr. H.H. Hallenquist, Dr. H.C. Hallenquist and Dr. S. Nixon.

Dr. B.W. Wood practiced in Gladewater from 1910 until 1915 and lived in the Bray Hotel.

Dr. T.J. Allison was b. July 28, 1850 and practiced medicine around Gladewater for 50 years. Legend has it that he was a very charitable & generous man. He would frequently buy medicine for an indigent family and wrap it in a 5 or 10 dollar bill. He also built the first organ in Gladewater and was an accomplished musician.

From 1906 until 1910, Dr. C.L. Hudson and Dr. M.F. Bettancourt practiced in Gladewater. Their offices were located were the old K. Wolens store (now the Gladewater Antique Mall) was.

In 1931, when the oil boom hit, there were 4 doctors in Gladewater.
Dr. E.G. McLaughlin
Dr. E.L. Walker
Dr. J.N. Whittle
Dr. A.G. Pritchett

Doctors listed in the late 1940's on funeral home records were:
Dr Bain Leake
Dr A R Hancock
Dr Carl Nichols
Dr C D Halley
Dr J C McKean
Dr C S Bloom
Dr Moser
Dr Howard Lebus
Dr Allie Mackey Brazzil
Dr Van Beber
Dr Cacey
Dr J B Hall

Dr. McLaughlin came to Gladewater around 1913. He had several hospital beds over Zeke Martin's Drug store and his office was on the corner of Upshur & Main St. He was the "inventor" of a chest rub called "Nu-Ma-Cide" and proved that it would penetrate the skin and be absorbed into the body by testing it on a skeptical physician and then checking his urine content one hour later. One of the main ingredients was Iodine. In a 1924 paper he had an ad which read:
Chronic Diseases a Speciality. Thoroughly equipped with apparatus to give the most approved treatments in all chronic conditions, much work done....that was formerly done with a knife. Thorough examination made and diagnosis made before attempting treatment.
Graduate Nurse in Attendance.

Dr. Walker had a large family practice and built the house that is now known as the Jack Finley home. When he built the house he had visions of converting it into a hospital. His office was in a local drug store, called The Purity, which he owned and operated. Dr. Walker was a brother of Billie Walker.

Dr. Whittle practiced in Union, Miss. before coming to Gladewater. He acquired extensive farm land in the Friendship Community just outside of Gladewater. His office was in the Whittle building on the corner of Main St. and Glade, and his home was on the corner of Main St. and Gregg. He was known as a southern gentleman and had the reputation of being a good pneumonia doctor.

Dr. Pritchett had a large family practice. His office was in his home at the corner of Quitman and Dean street.

In 1973 the doctors in Gladewater were: Dr. Bain Leake, Dr. A.R. Hancock, Dr. Howard LeBus, Dr. Charles Bloom, Dr. Charles Ben McKenzie, Dr. G. Robert Hugman, Dr. Geln Kent, Dr. E.R. Moser and Dr. Walter Hart.